The goal of the VIAV programme is to develop a novel, broadly effective HIV/AIDS vaccine based on HIV Tat and Env protein complexes. VIAV is built upon an international consortium of European experts in the fields of HIV/AIDS protein structure and molecular modelling/docking, biochemistry, molecular biology, virology, immunology, vaccine development, GMP production, trial conduction and field studies.

Background: Results obtained by the VIAV Consortium indicate that the HIV Tat protein increases HIV cell adsorption, infectivity and tropisms by interacting with components of the HIV membrane and envelope protein (Env). Because the interaction between Tat and Env may allow the generation of complex-specific, neutralisation-sensitive epitopes and/or the stabilisation of cryptic and/or transiently exposed Env epitopes, a vaccine based on Tat-Env complexes is likely to generate protective immune responses against vulnerable viral targets.

Aim: The aim of VIAV is to develop a highly innovative Tat-Env complex-based vaccine capable of inducing cross-clade neutralising antibodies against novel, neutralisation-sensitive Env epitopes to prevent HIV infection and/or AIDS progression. The VIAV aim will be achieved through new antigen design stemming out from novel virological, immunological and modeling data of the VIAV Consortium.

Expected results: The VIAV project will allow the identification of novel HIV/AIDS vaccine immunogens and formulations for the induction of broad immunity against HIV. Tat-Env complexes will be characterised and used to immunise small animals, where vaccination is expected to be safe and immunogenic. Neutralising antibody responses will be also characterised and novel neutralisation-sensitive, complex-induced epitopes will be identified.

Potential applications: The VIAV programme will bring specific contributions to AIDS vaccine research and development in terms of innovative vaccine formulations. In particular, the exploitation of novel vaccine formulations based on newly-identified/produced protein complexes that are potentially relevant in the context of HIV natural infection may directly result from VIAV. VIAV is an ambitious project that will fit in the scientific effort aimed at developing innovative AIDS candidate vaccines, based on combinations of regulatory and structural viral proteins. VIAV is also linked to the AIDS Vaccine Integrated Project (AVIP), recently awarded by the EU Commission, for future product development and clinical testing.

Coordinator: Flavia Ferrantelli National AIDS Center
Istituto Superiore di Sanità

Viale Regina Elena 299 00161 Rome Italy

 Tel: +39 06 4990 3209 Fax: +39 06 4990 3002

E-mail: flaviafr@iss.it Website: http://www.iss.it

Partners

N.	Principal Scientific Participants	Official Address	Other Information
1	Flavia Ferrantelli	National AIDS Center Istituto Superiore di Sanità Viale Regina Elena 299 00161 Rome Italy	Tel: +39 06 4990 3209 Fax: +39 06 4990 3002 E-mail: flaviafr@iss.it Website: http://www.iss.it
2	Banci Lucia	Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine Paramagnetiche Via L. Sacconi 6 IT-50019 Sesto Fiorentino Italy	Tel: +39 055 457 4263 Fax: +39 055 457 4253 E-mail: banci@cerm.unifi.it Website: http://www.cerm.unifi.it
3	Eva Maria Fenyo	Lunds Universitet Solvegatan 23 SE-22362 Lund Sweden	Tel: +46 46 17 3275 Fax: +46 46 17 6033 E-mail: Eva_maria.fenyo@mmb.lu.se Website: http://www.lu.se
4	Dag Helland	Universitetet I Bergen Museplass 1 5020 Bergen Norway	Tel: +47 55 58 45 19 Fax: +47 55 58 96 83 E-mail: dag.helland@mbi.uib.no Website: http://www.uib.no
5	Elisa Gargiulo	DIATHEVA srl Viale Piceno 137/F IT-61032 Fano Italy	Tel: +39 0721 830 605 Fax: +39 0721 837 154 E-mail: r&d@diatheva.com Website: http://www.diatheva.com
6	Mauro Magnani	University of Urbino  Institute of Biological Chemistry 'G. Fornaini' Via Saffi, 2 IT-61029 Urbino Italy	Tel: +39 0722 305211 Fax: +39 0722 320188 E-mail: magnani@uniurb.it
7	Antonella Caputo	University of Padova Department of Histology, Microbiology, and Medical Biotechnology Via A. Gabelli 63 IT- 35122   Padova Italy	Tel: +39 049 8272340 Fax: +39 049 8272355 E-mail: mcpa@dns.unife.it
8	Riccardo Gavioli	University of Ferrara  Laboratory of Cellular and Molecular Oncology, Department of Biochemestry and molecular Biology Via Fossato di Mortara, 74 IT-44100  Ferrara Italy	Tel : +39  0532 424407 Fax: +39 0532 424484 E-mail: r.gavioli@unife.it